Chronic fatigue syndrome belongs to the category of “deficiency labor, insomnia, and depression” in Chinese medicine, and is commonly treated with Chinese medicines such as Qui Spleen Pills and Pai Zi Nourishing Heart Pills. 1. Gui Spleen Pill: the formula is Codonopsis, fried atractylodes, roasted astragalus, roasted licorice, poria, systematic farzhi, fried sour jujube nut, longan meat, angelica, wood incense, etc. It has the efficacy of benefiting qi, strengthening the spleen and nourishing the blood to calm the spirit; it can treat deficiency of heart and spleen, shortness of qi and palpitation, insomnia, dizziness, tiredness and weakness, and loss of appetite. Adverse reactions of Gui Shen Wan, there are digestive discomfort, skin rashes; cold and fever people should not use; bleeding tendency patients should also not take; pay attention to avoid indigestible food. 2. Cypress Nourishing Heart Pill: composed of cypress seed kernel, Radix et Rhizoma Ginseng, Radix Astragali, Rhizoma Ligustici Chuanxiong, Radix Angelicae Sinensis, Poria, Radix Polygoni Multiflori, Radix Jujubae Souris and so on. Adverse effects, contraindications and precautions of Pai Zi Nourishing Heart Pill are not clear. If you need to treat the disease, you need to be guided by a traditional Chinese medicine practitioner to use the medicine, do not use the medicine arbitrarily, so as to avoid adverse consequences.