Aspirin mechanism of action

Aspirin mechanism of action can inhibit prostaglandin synthesis, anti-platelet aggregation and other effects. Pay attention to the contraindications and adverse effects of the drug, it is recommended to follow the doctor’s instructions for the use of drugs. Aspirin belongs to a kind of non-steroidal anti-inflammatory drugs, can inhibit the activity of the body cyclooxygenase-2 (COX-2), reduce the synthesis of prostaglandins, can play an anti-inflammatory, analgesic effect. It can effectively inhibit the generation of platelet thromboxane A2 and thus inhibit the role of platelet aggregation. Aspirin can through the hypothalamus thermoregulation center, can play a peripheral vasodilatation, thus increasing the skin sweating, thus playing a cooling effect. It is mainly used for the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases, the prevention of deep vein thrombosis, pulmonary embolism and other diseases. Taken in large doses it can relieve pain symptoms caused by toothache, neuralgia, menstrual pain, treat rheumatoid arthritis, osteoarthritis and other diseases. It is contraindicated in cases of allergy to the components of the drug, active peptic ulcer, severe heart, liver and kidney failure, late pregnancy. There may be adverse reactions such as dyspepsia, gastrointestinal bleeding, bleeding gums, skin rash. It is recommended that the medication be administered under medical supervision.