Chronic renal failure can lead to disorders of electrolyte and acid-base balance. In chronic renal failure, due to small or no urine, fluid cannot be discharged from the body, resulting in water and sodium retention, and potassium ions cannot be discharged with urine, resulting in hyperkalemia and hypernatremia. In chronic renal failure, bone metabolism is easily disturbed, and the ability of vitamin D hydroxylation is reduced and cannot be converted into active vitamin D3, resulting in reduced calcium absorption and hypocalcemia, and disorders of calcium and phosphorus metabolism resulting in hyperphosphatemia. The above analysis concludes that patients with chronic renal failure are prone to changes in electrolytes such as hyperkalemia, hypernatremia, hypocalcemia and hyperphosphatemia.