The thickening of the intestinal wall of the ascending colon can be seen in colitis, colon polyps and colon cancer, etc. It is recommended to improve the colonoscopy.1. If it is colon inflammation, it can be treated with medications to protect the intestinal mucosa, commonly used are montelukast, L-glutamine, and oral treatment with Chinese medicine.2. If the colonoscopy is colon polyps, it is best to perform endoscopic colon polypectomy if the pathology is taken. If colonoscopy is colon cancer, surgery is the first choice if no distant metastasis is found. If distant metastasis has been found, surgery is not indicated. Palliative treatments such as radiotherapy or chemotherapy can be chosen to improve the patient’s symptoms and enhance his or her quality of life. The thickening of the wall of the ascending colon is thought by many people to be colon cancer, but in fact, it is not. In most cases, the test is colitis or colon polyps. These benign lesions can be treated after systematic and standardized treatment.