The causes of Tourette’s syndrome are still not very clear, and may be related to genetic factors, central nervous system damage and pathological changes, psychological factors, immunity and drug factors. 1. Genetic factors: most scholars believe that the disease is polygenic, and studies have found that autosomal 13g31 may be a candidate gene for the cause of the disease. 2. Central nervous system injury and pathological changes: may be associated with perinatal complications, such as birth injury, asphyxia, preterm labor, low birth weight, and head trauma. It may be related to excessive dopamine release or hypersensitivity of postsynaptic dopamine D2 receptors, hyperfunction of the central noradrenergic system, endogenous opioid peptides, 5-HT, etc. 3. Psychological factors: Various psychological factors encountered by children in family, school and society, or causes of tension and anxiety in children may induce tic symptoms, or aggravate tic symptoms. 4. Immunity: Some studies have reported that tic disorders may be related to autoimmunity caused by beta-hemolytic streptococcal infection. 5. Drugs: Central stimulants and certain antipsychotics may also induce or aggravate the disorder. Tourette’s syndrome has a great impact on the social function and quality of life of children, and it is recommended to treat it as early as possible to avoid aggravation of the condition and adverse consequences.