High uric acid in a 50-year-old male patient may be due to excessive production of uric acid, blood system diseases, kidney disease and drugs. 1. Excessive production of uric acid: patients consume too much animal offal, beans and soy products, seafood, broth and other high-purine diet, drinking alcoholic beverages or enhancement of the metabolism of nucleic acids may lead to excessive production of uric acid. 2. Blood system diseases: Lymphoma, hemolytic anemia, multiple myeloma and other blood system diseases can lead to excessive production of uric acid due to the breakdown of nucleic acid in the cells, which in turn leads to the increase of blood uric acid level. 3. Kidney disease: most of the uric acid is metabolized by kidneys, therefore, kidney diseases such as renal insufficiency and tubular lesions may lead to impaired uric acid excretion, thus resulting in elevated uric acid levels in the body. 4. Drugs: Furosemide, hydrochlorothiazide, pyrazinamide, cyclosporine A, tacrolimus and other drugs may also lead to increased uric acid. Elevated uric acid may be caused by other reasons, it is recommended that patients with high uric acid go to the rheumatology and immunology departments of regular hospitals for detailed consultation.