Statin generally refers to statins, and it is recommended to take statins at intervals of more than half an hour after taking diclofenac sodium extended-release tablets. Diclofenac sodium extended-release tablets belong to non-steroidal anti-inflammatory drugs, with anti-inflammatory and analgesic effects. Adverse reactions are more frequent, gastrointestinal reactions are heavier, and they are contraindicated in patients with allergies, active or previous peptic ulcers, bleeding, severe heart failure, and severe hepatic, renal and cardiac failure. Liver and kidney function should be monitored regularly during the medication period, among other things. Statins are lipid-lowering drugs, including Rosuvastatin, Atorvastatin, etc. They are commonly used in the treatment of hypercholesterolemia, coronary heart disease and cerebral infarction. Common adverse reactions include liver injury, rhabdomyolysis and myopathy. It is contraindicated in women with active liver disease, allergy, pregnancy and lactation. Liver function and muscle enzymes should be monitored regularly during medication. When it is necessary to take diclofenac sodium extended-release tablets and statins at the same time, it is better to take them at intervals of more than half an hour. The application of specific drugs should be taken under the supervision of a doctor, do not use on their own.