Chronic lymphocytic leukemia does not have the typical five major symptoms, which are systemic symptoms, anemia, hepatosplenomegaly, hemorrhage, and infection. 1. Systemic symptoms: Early stage of chronic lymphocytic leukemia will have symptoms such as night sweats, extreme fatigue, low-grade fever and weight loss. 2. Anemia: patients may have anemia, which is caused by decreased hematopoietic function of bone marrow or hemolysis. 3. Enlarged liver and spleen: some patients have enlarged spleen and some have enlarged liver. 4. Bleeding: the main symptoms are skin ecchymosis, extensive bleeding and bruises. 5. Infection phenomenon: in mild cases, only upper respiratory tract infection occurs, but in serious cases, it can lead to lung infection or even systemic infection. Patients need to go to the hospital in time, if meet the treatment indications, it is recommended to receive timely treatment without delay.