Drinking coffee is not recommended after rabies vaccination, mainly because it can cause reactions such as palpitations and headache, which are difficult to distinguish from the adverse reactions after vaccination. Rabies vaccination will stimulate the body to produce an immune response to fight against rabies virus infection. However, rabies vaccination may also produce some adverse reactions, such as headache, dizziness and fatigue, which usually subside within a few days. During this period, it is not recommended to drink coffee to refresh yourself. Coffee contains caffeine, which may cause headache, dizziness, fatigue and other reactions, and it is difficult to distinguish these reactions from the vaccine-induced adverse reactions, which may confuse the judgment of the occurrence of adverse reactions, resulting in adverse consequences. In addition, rest should be paid attention to after vaccination in order to better promote the immune system to produce an immune response. In order to avoid insomnia caused by drinking coffee and affecting rest, it is not recommended to drink coffee after rabies vaccination.