Painful eyes when looking upward may be caused by upper eyelid impingement, inflammation of the eyelid glands, or retrobulbar optic neuritis. 1. Upper eyelid impingement: If you have upper eyelid impingement, the cornea will be easily irritated when you turn your eyes upward gradually, so you will experience pain. 2. Blepharitis: Blepharitis, also known as granuloma, is usually related to Staphylococcus aureus infection, and if it occurs in the upper eyelid area, it is usually painful when the eye is turned upward. 3. Posterior bulbar optic neuritis: Posterior bulbar optic neuritis is also more common in our lives, usually with pain in the eyeball rotation, and may also have vision pain when the eye looks up. It is recommended to go to the ophthalmology department of the regular hospital in time to clarify the specific cause, and then follow the doctor’s instructions for treatment, so as not to affect the health of the eyes.