The pain in the stomach and spitting out bitter water is usually caused by gastritis, reflux esophagitis, cholecystitis, gallstones, etc., and can be treated with medicines to protect the gastric mucosa, anti-inflammatory bile and anti-infection. 1. Drugs to protect the gastric mucosa: the pain in the stomach may be due to gastritis, reflux esophagitis, recommended the use of magnesium aluminum carbonate, aluminum carbonate and other drugs to protect the gastric mucosa for treatment. 2. Anti-inflammatory choleretic drugs: if the gallbladder inflammation may also make the patient appear stomach discomfort and pain, cholecystitis combined with bile reflux, the patient may also appear to spit out the bitter water, at this time it is usually recommended to use cephalosporins, anti-inflammatory choleretic tablets and other anti-inflammatory choleretic drugs for treatment. 3. anti-infective drugs: a burst of pain in the stomach to spit out the bitter water may also be gallstones embedded, it is recommended that the use of amoxicillin, ceftazidime and other drugs for treatment. Drugs need to be used under the guidance of a doctor, if the patient’s stomach a burst of pain spit out bitter water symptoms are serious, or the symptoms continue and did not get better, should go to the hospital in time for treatment.