Staphylococcus cephalis is a type of staphylococcus, a gram-positive cocci that can cause purulent inflammation, and bone marrow infection with Staphylococcus cephalis can lead to septic osteomyelitis. Staphylococcus cephalosporus is a gram-positive coccus that can cause purulent inflammation, and bone marrow infection with Staphylococcus cephalosporus can lead to septic osteomyelitis, which can be caused by hematogenous infections, traumatic infections, and spread of peripheral infectious lesions. Clinical symptoms of septic osteomyelitis include fever, localized redness, swelling and heat pain, etc. Blood test, CT examination, blood culture and other tests can assist in the definitive diagnosis, and antibiotics (such as cefoperazone sodium sulphadiazine sodium, etc.) are needed to fight infection. Bone marrow infection with Staphylococcus cephalosporus requires timely consultation and proper treatment to avoid delay.