Multiple small lymph nodes in the root of mesentery and ileocecal region, which refers to the increase or enlargement of lymph nodes in the root of mesentery, may be caused by intestinal inflammation, lymphoma and other reasons. 1. Intestinal inflammation: it may be caused by bacterial or viral infection, or autoimmune disease, parasitic disease, etc. It may cause abdominal pain, diarrhea, blood in stool, etc. It may also cause multiple small lymph nodes in the root of mesentery and ileocecal region, and it can be taken medicines such as omeprazole, rabeprazole, etc. under the guidance of doctor. 2. Lymphoma: it is a malignant tumor originated from lymphohematopoietic system, and may cause fever, night sweating, emaciation and other symptoms, which may be caused by viral factors or autoimmune diseases, etc. It can be cured by chemotherapy and radiotherapy, etc., to control the spread of cancer cells. Small lymph nodes in the root of mesentery and ileocecal region, once found, need to go to the hospital for further examination of the specific cause of the disease, so as to make a clear diagnosis and give treatment as early as possible. Adopt good living habits on weekdays, prohibit smoking and drinking, pay attention to balanced nutrition, and eat more fresh fruits and vegetables.