Trimethoprim cream needs to be discontinued on medical advice according to the individual’s condition and the location of the disease. Normally, trimethoprim cream should not be used continuously for more than 4 weeks, and should not be used continuously for more than 2 weeks on thin skin. Trimethoprim cream is a compound preparation, commonly used in the treatment of seborrheic dermatitis, neurodermatitis, eczema, tinea corporis, ringworm and other diseases. Normally, this product should not be used continuously for more than 4 weeks; it should not be used continuously for more than 2 weeks on thin skin areas such as the face, groin and vulva. Prolonged use of this drug may cause localized skin atrophy, capillary dilatation, hirsutism and secondary infections. Some patients may experience adverse reactions such as allergy, burning sensation on the skin and itching after using this drug. It should be noted that allergic individuals should be cautious, and those who are allergic to this product are prohibited from using it. Trimethoprim cream should not be used continuously for more than 4 weeks, and should not be used continuously for more than 2 weeks on thin skin. It is necessary to use and stop the drug under the guidance of the doctor, and should not stop the drug without authorization to avoid abnormalities.