Lung cancer bone metastasis with severe leg pain can be relieved by pain-relieving medication, radiotherapy and targeted drug therapy under doctor’s guidance. 1. Pain-relieving drug treatment: under the guidance of doctors, drugs such as oxycodone and morphine can be used to relieve pain. Zoledronic acid, bisphosphonates and sodium ibanophosphate can also be applied to reduce bone destruction and alleviate pain. 2. Radiotherapy: Palliative radiotherapy for bone metastasis can relieve pain and delay bone destruction. Chemotherapy mainly adopts cisplatin-based chemotherapy program. 3. Targeted drug therapy: actively treating the primary disease through molecular targeted therapy can alleviate the uncomfortable symptoms. Commonly used drugs include Gefitinib, Ectinib, Crizotinib and Anrotinib. If the symptoms cannot be relieved, it is necessary to consult a doctor in time and actively cooperate with the treatment.