Hereditary spherocytosis and leukemia are two completely different diseases in the hematological system, and spherocytosis will not be transformed into leukemia. 1. Hereditary spherocytosis is a common hereditary hemolytic anemia, which is an autosomal dominant disease. 2/3 of the population develops in adulthood, with jaundice, anemia and splenomegaly as the main clinical manifestations. 2. Leukemia is a kind of malignant tumor that occurs in the hematopoietic system. Its main feature is the unrestricted proliferation of leukocytes in body tissues, and all organs of the body can be infiltrated; there can be the presence of primitive and infantile leukocytes in the blood circulation of the whole body. The clinical symptoms of leukemia are mainly anemia, fever, bleeding, liver and spleen enlargement, lymph node enlargement, and sternal pressure pain. Although anemia occurs in both diseases, the hemolytic anemia of hereditary spherocytosis is caused by defective red blood cell membranes and poor deformability, and leukemia is caused by inhibition of normal hematopoiesis resulting in a decrease in red blood cells. Both have different pathogenesis and treatment. For specific knowledge, consult a hematologist.