Hypertension usually requires long-term medication and can be harmful, such as headaches, vertigo, and postural hypotension. Different types of anti-hypertensive drugs have different adverse effects. Specific drugs should be analyzed. Diuretics such as hydrochlorothiazide can lead to electrolyte disorders: low blood potassium, low blood magnesium, low blood sodium, high blood ammonia, etc., and metabolic abnormalities: high blood glucose, high blood lipids, high uric acid, etc. Calcium channel blockers such as amlodipine, common adverse effects include facial flushing, headache, vertigo, palpitations, and ankle edema. Renin angiotensin system inhibitors such as captopril and chlorosartan, adverse effects include hyperkalemia, hypotension, irritating dry cough, and angioneurotic edema. Beta-blocking drugs such as propranolol, adverse reactions include nausea, vomiting and other gastrointestinal reactions, and in severe cases there are induced or exacerbated bronchial asthma, severe cardiac insufficiency, pulmonary edema and so on. In addition to these antihypertensive drugs, there are many drugs with different mechanisms of action, about the adverse reactions are also different, should be specific drug specific analysis, make corresponding measures to minimize the harm caused by long-term drug use.