HPV53 positive, whether you need treatment, can not be generalized, no symptoms without treatment; if there are viral warts need to be treated. 1. No need to treat the situation: male HPV53 positive, if only hidden infection body without any symptoms, without special treatment, pay attention to hygiene, more exercise, improve immunity, most of them will turn negative. 2. need to be treated: male HPV53 positive, if the body has viral warts (warts, flat warts, common warts, etc.), need to take appropriate measures to remove warts. HPV53 positive men should actively seek medical attention, under the guidance of the doctor to decide whether the need for treatment.