Serious hyperpigmentation on the neck may be a physiological phenomenon, but also may be post-inflammatory hyperpigmentation, acanthosis nigricans and other pathological factors, according to the cause of the choice of general treatment, medication, physical therapy and other ways to remove. 1. Normal physiological phenomenon: prolonged friction, sunlight exposure can lead to serious hyperpigmentation on the neck, usually can wear some loose clothes to avoid friction, daily attention to sunscreen, for the cosmetic requirements of the patient can be used to reduce the symptoms of laser and other physical therapy. 2. Pathological factors Post-inflammatory hyperpigmentation: you can use local deoxy arbutin ointment, hydroquinone cream to inhibit the activity of tyrosinase class of drugs applied locally, you can also use some drugs to inhibit the formation of melanin, such as aminomethylcyclic acid and other drugs to reduce local symptoms, and if necessary, can also be combined with laser treatment. Echinococcus nigra: Echinococcus nigra can also lead to neck hyperpigmentation, you should actively search for the cause of the disease, standardize the treatment of the cause of the disease, the general symptoms can be relieved. Neck hyperpigmentation is serious, it is recommended to go to the regular hospital in a timely manner, under the guidance of specialists to carry out active treatment, do not take medication without authorization, to avoid adverse reactions.