Cefixime and cefaclor can be taken for otitis media. Cefixime is a third-generation cephalosporin, which is relatively less harmful to liver and kidney, while cefaclor is a second-generation cephalosporin, but it is also effective for otitis media caused by sensitive bacteria. For otitis media, it is best to take a combination of systemic and local medication. Local otitis media can be treated with oxyfloxacin ear drops, plus oral cephalosporin or penicillin antibiotics, which are ideal for treating otitis media.