In addition to treating the root cause of edema, diuretics should also be given. There is no absolute “fastest way”. 1. Renal disease: when the glomerular filtration barrier is damaged, proteinuria, plasma albumin will be reduced, resulting in the water in the blood vessels seeped into the tissue space, which can lead to eyelid edema and double lower extremity swelling. Glucocorticosteroids such as prednisone acetate can be prescribed to control the condition, thus reducing proteinuria, and the swelling can subside naturally after plasma albumin is raised. 2. Liver disease: the liver can not synthesize enough albumin, the plasma colloid osmotic pressure decreases significantly, and generalized edema occurs. Albumin infusion and diuretics such as furosemide can be used to treat the primary disease. 3. Heart disease: Heart failure leads to decreased venous return and sodium retention, which stagnates blood in the venous system and increases venous pressure, which in turn causes an increase in capillary hydrostatic pressure, leading to obstruction of tissue fluid and lymphatic return and causing tissue edema. Therapeutically, diuretics should be given in minimal doses for long periods of time. Commonly used diuretics include hydrochlorothiazide, furosemide, and spironolactone. Patients taking diuretics for a long time should pay attention to the occurrence of hypokalemia. 4. Metabolic diseases: hypothyroidism appears edema mainly in skin and connective tissue changes, causing mucous edema. Thyroxine tablets can be taken under the guidance of the doctor to reduce the effect of edema. These are only some of the common causes. Swelling in the legs should be treated as soon as possible after the diagnosis has been made and the treatment is standardized according to the doctor’s instructions. The use of drugs must follow the doctor’s instructions, not blindly use their own drugs, so as not to cause adverse consequences.