Adverse drug reactions that may occur when glucocorticoids are taken for long periods of time and in larger doses include infections, skin acne, peptic ulcers, diabetes mellitus, osteoporosis, and full moon face. Glucocorticoid drugs such as betamethasone, hydrocortisone, and dexamethasone usually provide anti-shock, anti-inflammatory, and anti-allergic effects and are widely used for a variety of diseases. Adverse drug reactions that may occur when glucocorticosteroids are taken for a long period of time and in larger doses are skin acne, peptic ulcers, amenorrhea, weakness, buffalo back, diabetes, hyperlipidemia, osteoporosis, full moon face, and hirsutism. In addition to this, long-term use of glucocorticosteroids in high doses may lead to weakening of the patient’s body resistance, inhibition of growth and development of children, as well as impeding tissue healing, while short-term, small-dose use of glucocorticosteroids is less likely to have adverse drug reactions. Glucocorticosteroids are contraindicated in people who are allergic to glucocorticosteroids, and should not be used in patients with active peptic ulcers or bleeding, hypertension or diabetes mellitus. Pay attention to the prevention and control of infection during the use of the drug, monitoring blood glucose and blood pressure. After long-term use, gradually reduce the dosage before stopping the drug. Glucocorticosteroids need to be used under the guidance of a physician, and it is recommended that patients who need to take glucocorticosteroids go to the relevant departments of regular hospitals for detailed consultation.