Clinically there is no best way to make the penis bigger and thicker, patients need to choose the appropriate method of treatment according to their own situation. If the patient is underage, you can use human chorionic gonadotropin, luteinizing hormone-releasing hormone, testosterone undecanoate, dihydrotestosterone and other androgenic medications under the guidance of a doctor, which can promote the continued development of the penis, and play the role of enlargement and thickening of the penis. All the above drugs need to pay attention to the side effects and adverse reactions, please use the above drugs under the guidance of a doctor. If a patient is an adult and wants to enlarge and thicken his penis, usually he can only choose surgery, such as penis lengthening and thickening surgery or penis reconstruction surgery, etc. However, there are certain risks associated with the surgery and it may not be able to achieve the expected results, so the patient should be fully aware of the contents of the surgery and make a careful choice. Usually, the length and diameter of the penis will not directly affect the sexual and reproductive functions, if the patient has the need to enlarge the penis, please consult a regular hospital.