The specific causes of SLE have not yet been clarified, and may be related to genetic, endocrine, environmental and immune abnormalities.
1. Heredity: The onset of SLE has a tendency of family aggregation, and the relatives of patients have a higher chance of developing SLE compared with normal people, suggesting that the onset of SLE may be related to genetic predisposition.
2. Endocrine: abnormalities in sex hormones such as estrogen and its metabolism are associated with the onset of SLE, and the prevalence of SLE in women is significantly higher than that in men.
3. Environment: Environmental factors known to be associated with the development of SLE include infections, sunlight, drugs and chemicals, etc. Ultraviolet light can lead to apoptosis of skin epithelial cells and induce SLE, and drugs such as procainamide and infections of pathogens such as EBV may also be the cause of SLE.
If the diagnosis of SLE is confirmed, patients should go to the rheumatology and immunology department of regular hospitals and follow the doctor’s instructions for standardized treatment.