If a 49-year-old woman’s menstruation is not clean for more than 10 days, it may be caused by insufficient estrogen secretion, endometrial hyperplasia, cervicitis, etc. She needs to be treated with estrogen supplementation, insertion of levonorgestrel intrauterine device, and oral antibiotics. 1. Supplementation of estrogen: Inadequate hormone secretion and abnormal ovulation in 49-year-old women will lead to abnormal growth of the uterine lining and symptoms of irregular menstruation. Supplemental estrogen such as estradiol can be prescribed by the doctor to raise the level of estrogen in the body and relieve the symptoms of irregular menstruation. 2. Implantation of levonorgestrel intrauterine device: Diseases such as endometrial hyperplasia can lead to prolonged menstruation. Levonorgestrel intrauterine device can be inserted to slowly release progesterone to control endometrial hyperplasia and alleviate the symptom of prolonged menstruation. 3. Oral antibiotics: Cervicitis and other diseases can lead to cervical blood secretion formation, and prolonged menstruation. You can take oral penicillin and cephalosporin antibiotics as prescribed by your doctor for anti-inflammatory treatment. If a 49-year-old woman has a menstrual period of more than 10 days, she needs to go to the hospital for an examination to clarify the cause of the disease and then treat the symptoms. All of the above medications should be used under the guidance of a doctor, avoid self-medication.