The presence of one nostril out of breath and one out of breath may be caused by chronic simple rhinitis, deviated nasal septum, and nasal mass. Nasal decongestants, glucocorticoid nasal sprays, nasal septum correction, and resection of nasal masses can be applied for treatment. 1.. Chronic simple rhinitis: it is a kind of chronic inflammation of the nasal cavity mainly characterized by swelling of the nasal mucosa and increased secretion. Nasal congestion is characterized by intermittent and alternating nasal congestion, treatment can be applied 0.5%-1% ephedrine solution or 0.05% hydroxymetazoline nasal drops, usually not more than 7 days, corticosteroid nasal sprays, such as budesonide nasal spray nasal spray; nasal rinsing; traditional Chinese medicines such as Tongkong rhinitis granules treatment. 2.. Deviated septum: Patients with deviated septum due to genetic factors, trauma, developmental abnormalities, etc. will also have one nostril out and one out, which can be treated by septoplasty and septal correction. 3. Nasal mass: Most of the unilateral nasal mass, such as maxillary sinus posterior nostril polyp, inverted papilloma, etc., cause the nostril of the side of the mass to be out of breath. Surgical removal of the mass is required to resolve unilateral nasal congestion. Patients should go to the hospital for examination and treatment when one nostril is out of breath and the other is not. Medications should also be used under a doctor’s supervision.