The symptom of generalized itching after blood transfusion should be considered as transfusion allergic reaction, which is a common complication of blood transfusion. Mild symptoms are often relieved by oral antihistamine drugs (such as phenylephrine, ipecac, etc.), and in severe cases, respiratory distress may occur, and intravenous glucocorticosteroid may be given, and tracheotomy may be performed if necessary. Allergic reaction is one of the common complications of blood transfusion, which may only manifest as skin itching or urticaria, and the symptoms can usually be relieved by oral antihistamines (such as benadryl, ipratropium, etc.). However, due to severe allergy will appear bronchospasm, laryngeal edema, and then lead to respiratory distress, even anaphylactic shock or even death, so the development of the disease should be closely observed, such as symptoms worsening can be given intramuscular injection of epinephrine or intravenous glucocorticoids, combined with respiratory distress should be endotracheal intubation or incision, to avoid asphyxiation. Do not be negligent when generalized itching occurs after blood transfusion, seek medical treatment in time and closely observe the development of the disease.