Despite the obvious advantages of monotherapy, some patients still do not have good seizure control after monotherapy and should consider multidrug combination therapy at this time. The principle of multidrug combination therapy is to obtain satisfactory seizure control without increasing adverse effects. Since the more drugs are combined, the more complex the interactions and the more difficult it is to determine adverse effects, it is recommended not to combine more than three antiepileptic drugs. It is important to understand the mechanism of action, pharmacokinetic characteristics, and the interactions with other drugs before combining multiple drugs, which is the basis for reasonable multi-drug combination therapy. The combination of antiepileptic drugs with the same mechanism of action and the same side effects, as well as the combination of drugs with obvious pharmacokinetic interactions, should be avoided. A few suggestions for the selection of drugs for multidrug combination therapy 1. Select drugs with different mechanisms of action: for example, drugs with GABAergic-like effects combined with sodium channel blockers may produce better clinical efficacy. For example, the combination of carbamazepine, oxcarbazepine, lamotrigine, phenytoin sodium with sodium valproate, Toltea, gabapentin, and Kaipulan. Try to avoid the combined application of two sodium channel blockers or two drugs with GABAergic-like effects. 2. Avoid the combined application of drugs with the same adverse effects, complex interactions and hepatic enzyme induction. For example, Kaipuran and gabapentin rarely interact with other drugs and are suitable for combination with other drugs. Sodium valproate can prolong the half-life of lamotrigine and increase its plasma concentration, and its starting and maintenance dose must be adjusted. If the combination therapy still fails to achieve better efficacy, continue to adjust the drugs for combination therapy or switch to monotherapy, when the best balance between efficacy and adverse effects must be chosen and the complete control of seizures unnecessarily pursued.