Fever reducers for children with buttock plugs are relatively safe and rarely cause side effects if the applied dose is within the normal range. If the child’s constitution is very sensitive or the applied dose is too high, it can also cause side effects. First of all, it can cause diarrhea in children. The ingredients of antipyretic drugs are mainly non-steroidal anti-inflammatory drugs such as ibuprofen, which can cause diarrhea, abdominal pain and other gastrointestinal symptoms when administered in the intestinal tract. The second is excessive sweating. Some antipyretic drugs are more potent and can cause children to sweat more than usual, resulting in dehydration and electrolyte disorders. Finally, it can also cause damage to the liver and kidney function of children, if the dose of drugs applied to children is too large, and the liver and kidney function is very fragile, it can cause abnormal liver and kidney function.