Fasting blood glucose 10mmol/L should be used under doctor’s guidance to lower glucose, such as biguanide, sulfonylureas, DPP-4 inhibitors, SGLT-2 inhibitors and so on. 1. Biguanides: exert glucose-lowering effect by inhibiting hepatic glucose output and promoting the utilization of glucose by tissues, the common one is metformin, and the adverse effects of metformin include gastrointestinal reaction, lactic acidosis and so on. 2. Sulfonylureas: they are insulinotropic agents, which play a hypoglycemic effect by promoting insulin secretion, common ones are glimepiride and gliclazide, and their adverse effects include hypoglycemia, weight gain, and so on. 3. DPP-4 inhibitors: through the inhibition of DPP-4 and reduce the inactivation of GLP-1 in the body to play the role of hypoglycemia, common selegiline, ligustine, can have diarrhea, headache and other adverse reactions. 4. SGLT-2 inhibitors: by inhibiting renal tubular sodium-glucose cotransporter protein to promote glucose discharge from urine, inhibit absorption to play a hypoglycemic effect, common dagliflozin, engelecitabine, adverse reactions include urinary tract infections and so on. Fasting blood glucose 10mmol / L should go to the hospital, under the guidance of the doctor treatment, do not take medication on their own, such as blood glucose control is still not qualified, if necessary, insulin therapy.