Jaundice of 220 μmol/L needs to be judged as serious depending on age. In newborns, it may not be serious but requires vigilance. In adults, it is more serious and prompt medical attention is recommended. 1. Newborns: Normally, physiologic jaundice in full-term infants usually appears 2-3 days after birth, peaks in 4-7 days, and gradually subsides in 7-14 days, not exceeding 2 weeks at the latest, with jaundice values peaking at around 200-221 umol/L. In preterm infants, jaundice is usually more severe, but needs to be treated promptly. In preterm infants, the jaundice value usually does not exceed 255 µmol/L. The jaundice index of 220 µmol/L should be referred to the age of the newborn to see if it is within the normal range. If it is within the normal range, it will not affect the physical and neurological development of the newborn, but it is important to be vigilant and follow the pediatrician’s instructions. If the newborn’s jaundice rises too rapidly or does not decrease, it is recommended that the cause of the problem be identified and treated promptly. 2. Adults: Normally, the jaundice index in adults should be less than 17.1 µmol/L. If the jaundice index reaches 220 µmol/L, it is highly doubtful that liver impairment (hepatitis) has occurred, the metabolism/detoxification function of the liver has decreased, or there are problems such as obstruction, which may be aggravated with the progression of the disease if left untreated. Therefore, it is recommended to consult a doctor immediately, complete the relevant examinations, clarify the cause of the disease, and actively carry out the relevant treatment.