Trimebutine Maleate and Mosapride are both drugs that promote gastrointestinal motility, but the mechanism of action is different, Trimebutine Maleate has a two-way regulatory effect. Trimethoprim maleate is used for gastrointestinal dyskinesia caused by gastrointestinal dysfunction, with bidirectional regulation, both can inhibit too fast gastrointestinal peristalsis, also can promote too slow gastrointestinal peristalsis. General adverse reactions are tachycardia, headache, dizziness, drowsiness, urticaria, pruritus, dysuria, etc.; serious adverse reactions are hepatic impairment, jaundice. Mosapride belongs to the selective 5 hydroxytryptamine receptor agonist, after taking it can stimulate the gastrointestinal enhancement of power, used for functional dyspepsia with heartburn, nausea and vomiting, belching abdominal distension, abdominal pain and other digestive symptoms. Adverse reactions are mainly dry mouth, skin rash, occasional elevation of triglycerides, abnormal changes in electrocardiogram, or palpitations. The specific choice of medication is recommended to follow the doctor’s advice, not self-abuse.