Butalbital and rivaroxaban can be taken at the same time. Butanophthalein is an anti-ischemic drug, rivaroxaban is an anti-thrombotic drug, the two drugs have different pharmacological effects, and there is no antagonism between each other, can be used at the same time. Butylphthalide is a synthetic racemic n-butylphthalide, which can reduce cerebral edema, improve cerebral energy metabolism and ischemic brain microcirculation and blood flow, inhibit neuronal apoptosis, and has the effect of antithrombotic and antiplatelet aggregation, which has the effect of improving the impairment of central nervous system function of patients with cerebral infarction. Rivaroxaban is an oral factor Xa inhibitor with antithrombotic effects. The two drugs, butanephthalein and rivaroxaban, have different pharmacological mechanisms of action and are not antagonistic to each other, so they can be taken together. Adverse reactions such as transaminase elevation, nausea, abdominal discomfort may occur after taking butalbital, patients who are allergic to butalbital and patients with serious bleeding tendency are prohibited to use this drug. Adverse reactions such as bleeding, anemia, nausea may occur after taking rivaroxaban, patients who are allergic to rivaroxaban, patients with markedly active bleeding, pregnant and lactating women are prohibited from using this drug. If you need to take butylphthalide and rivaroxaban, please follow the doctor’s instructions for treatment.