How long you need to take medication for HPV (human papillomavirus) type 52 infection is determined by the type of treatment, the body’s immunity, and so on. Most cases require anywhere from 15 days to six months. HPV52 is a high-risk type of HPV, and long-term recurrent infections can lead to poor prognosis such as cervical cancer. For people who cannot achieve self-cure, medication is needed to help achieve viral conversion. The course of treatment is 3 months with alternating vaginal administration of Povidone suppositories and interferon gel; 30 days of interferon treatment is a course of treatment; and thymopeptide needs to be taken for 15 days to three months depending on the condition. Drugs should be used under the guidance of a professional doctor. For people with more serious conditions and weaker immunity, it is difficult to turn negative in one course of treatment, so it is necessary to extend the treatment cycle and start the next course of treatment. Therefore, in most cases, the medication should be used for 15 days to half a year. A small portion of the population can be in a long-term carrier state, requiring long-term medication. Therefore, patients must follow the doctor’s instructions to use medication. After HPV52 infection, cervical screening should be performed as prescribed by the doctor to avoid adverse prognosis.