Thigh pain and calf numbness may be caused by long-term compression, strenuous exercise and other physiological factors, but also lumbar disc herniation, lumbar spondylolisthesis, and lumbar spinal stenosis and other diseases. 1. Physiological factors: If you sleep or daily work and study, long-term compression of the legs or experienced strenuous exercise, will cause thigh pain calf numbness symptoms, is a normal physiological phenomenon. 2. Lumbar disc herniation:Lumbar disc herniation is caused by degeneration of the intervertebral discs, which will cause lumbar pain, leg pain, numbness of the lower limbs, intermittent claudication and other symptoms. Therefore, patients will have thigh pain calf numbness. 3. Lumbar spondylolisthesis:Lumbar spondylolisthesis is caused by spinal self-protection as well as self-repair, and the main symptoms are lumbar pain, lower extremity numbness, soreness, etc. Therefore, patients will have thigh pain and calf numbness. 4. Other:Lumbar spinal stenosis, peripheral neuritis and other diseases can also lead to thigh pain calf numbness. When the symptoms of thigh pain and calf numbness appear, you should consult a doctor in time and follow the doctor’s instructions.