Headache and aching limbs may be caused by fever, which can be seen in a variety of diseases, such as infectious diseases of the central nervous system, including encephalitis and meningitis. It can also be seen in lung infections and upper respiratory tract infections. Most patients with encephalitis are due to viral infections and patients can present with headache and fever, as well as nausea and vomiting. Some patients may present with somatic neurological signs and symptoms, such as hemiparesis and hemianopia, as well as psychiatric symptoms, and some patients may have seizures. The main treatment is antiviral therapy and cranial pressure lowering therapy if the patient has increased intracranial pressure. If the patient has meningitis, most of the symptoms are headache, nausea and vomiting. Patients can usually show signs of meningeal irritation, including positive Bruch’s sign and Kirsch’s sign, and can also show cervical tonicity. If the patient has an upper respiratory tract infection, anti-cold treatment is given, including cold capsules and cold pellets, and rest is given, and acetaminophen is given to lower the temperature when the body temperature rises. If the patient is a pulmonary infection, anti-infection treatment is generally given, commonly used drugs include cephalosporin antibiotics, such as ceftriaxone sodium and cefoperazone sulbactam, also can apply levofloxacin and so on.