Small blisters on the eyelids are firstly considered to be caused by allergies. Local itching, blisters, accompanied by local skin redness and swelling, are allergic symptoms after contact with allergens, allergic symptoms are more obvious during the decline of the body’s resistance, the main treatment is to promptly get rid of allergens, the use of anti-allergy drugs for treatment, local avoid repeated scratching, frequent cold compresses. Diet needs to avoid fish, seafood and other foods. Herpes zoster can have small blister-like changes locally, but herpes zoster does not exceed the midline and is confined to one side of the eye, which is a common disease in dermatology. When the eye is involved, there can also be tearing, photophobia and pain in the eye, which requires timely treatment with antiviral drugs, strengthening the body’s resistance or taking transfer factor and acupuncture to improve symptoms.