Simeglutide is used for the treatment of type 2 diabetes mellitus by promoting insulin secretion and inhibiting glucagon secretion to lower blood glucose. Simethicone can promote insulin secretion and inhibit glucagon secretion, at the same time, simethicone can suppress appetite, reduce the amount of food, promote gastric emptying, reduce the absorption of glucose, mainly used to lower blood sugar, can treat type 2 diabetes. Adverse reactions such as nausea and vomiting may occur during the use of simethicone, while the drug is contraindicated in patients who are allergic to simethicone, diabetic ketoacidosis, and type 1 diabetes. Simethicone should be used under medical supervision.