There is no particular association between malignant tumor pain and progression. Generally malignant tumor symptoms do not always manifest as pain, and even distant metastases have occurred at the time of discovery, but have not been causing painful symptoms either. However, some malignant tumors may invade the nociceptive nerve and cause pain, but it does not mean that it is deterioration. At this time, the degree of malignancy may not have any change, but only due to the invasion of local nociceptive nerve, so there is no necessary connection between malignant tumor pain and whether it is deterioration. Once patients feel pain, they should go to the hospital as soon as possible, and the doctor will help determine what causes the pain. If it is caused by malignant tumor, corresponding treatment should be carried out, including surgery, etc. Comprehensive treatment after surgery can also be carried out, including radiotherapy, chemotherapy, biological therapy, immunotherapy, Chinese herbal medicine treatment, etc. The main purpose of the above treatments is to prolong the survival time of patients and improve the quality of survival.