Manganese is useful externally for edema and can be used for many causes of edema or redness and pain. When used externally, mangosteen has the effect of clearing heat and reducing swelling, and has a good therapeutic effect on facial and limb edema caused by water-dampness internal stagnation (water-dampness stays in the body) and overflowing skin. However, pregnant women should be cautious of using Mangniu, and this product should not be used with sulfur and Sanling. This product is generally used externally for the treatment of edema, and should not be taken internally, so as not to lead to the emergence of abdominal pain, diarrhea, nausea, vomiting and other adverse reactions. Manganese can also be used for skin redness and swelling caused by trauma, such as redness and swelling after ankle sprains. Clinically, it can also be used to treat edema and swelling caused by fluid infiltration into subcutaneous tissues during infusion, as well as edema caused by heart failure, renal failure, hypoproteinemia, cirrhosis of the liver, and other causes of the body. All of the above cases can be used to apply Mannite externally, in order to reduce swelling and dissipate the knot, usually with more significant results. It is recommended that if patients have the need to use the external application of mangosteen, it should be used under the guidance of a doctor, and should not be used privately.