From fetal formation to aging is a gradual physiological process, which is also the process of development, maturation and decline of hypothalamic-pituitary-ovarian axis function. Women’s life can be divided into 7 stages according to their physiological characteristics: fetal, neonatal, childhood, puberty, sexual maturity, menopausal transition and late menopause, but there are no clear boundaries, and there are individual differences due to genetic, environmental and nutritional factors. When it comes to menopause, some women feel fearful and involuntarily associate it with aging, aging, youthfulness, disease, etc. So is menopause really that terrible? We should be aware that menopause is a phase that all women must go through. The menopausal transition refers to the period from the beginning of the menopausal trend until the last menstruation. It can start at age 40 and last as short as 1-2 years or as long as 10-20 years. During this period, the ovarian function gradually declines and the number of follicles decreases significantly and follicular dysplasia is likely to occur, resulting in irregular menstruation and often anovulatory menstruation. Eventually, ovarian failure occurs due to natural depletion of follicles in the ovary or loss of response to pituitary gonadotropins in the remaining follicles. The permanent cessation of menstruation is called menopause. The average age of menopause in our women is 49.5 years, with 80% between the ages of 44 and 54. Although life expectancy has increased significantly, the age of menopause has not changed much, implying that the age of menopause in humans depends mainly on genetics. The term “menopause” has been used to describe this particular period of biological change in women. Due to the ambiguity of the definition of menopause, in 1994 the WHO proposed to abolish the term “menopause” and recommended the term “perimenopause”, which is defined as the period from the onset of ovarian decline until one year after menopause. During perimenopause, the decrease in estrogen levels causes some women to experience: 1) symptoms of neurological and endocrine disorders, such as hot flashes, sweating, dizziness, palpitations, sensory disturbances, neurogenic hypertension, etc.; 2) psychiatric symptoms, such as insomnia, memory loss, anxiety, depression, etc.; 3) atrophic lesions, such as vaginal dryness, frequent urination, and stress urinary incontinence; 4) metabolic disorders: accelerated bone resorption process The bone loss develops rapidly in an exponential manner from the time when menopause is about to begin, and severe bone loss leads to osteoporosis and easy fracture; elevated serum cholesterol, triglycerides and LDL and lower HDL after menopause may lead to the occurrence of atherosclerosis, coronary heart disease and hypertension. These changes do not occur in everyone and vary from person to person. Some people do not experience much change and adapt quickly to this period; others seek medical help because these symptoms interfere with their daily life. In conclusion, menopause is a normal physiological and psychological reaction for women, please treat it correctly and don’t be afraid, family and friends should also show more care and love to women during this period, so that we can pass this period smoothly together.