Amlodipine benzenesulfonate can be used in combination with antihypertensive drugs such as valsartan, Benadryl and hydrochlorothiazide to increase the antihypertensive effect, and should be used under the guidance of a doctor. Amlodipine benzenesulfonate belongs to the dihydropyridine class of calcium channel antagonists (CCB), which can inhibit calcium inward flow, dilate peripheral blood vessels, and play a role in lowering blood pressure, but it should not be used in people with a history of allergy to this drug. The first-line combination regimen for hypertension includes: dihydropyridine calcium channel antagonist (CCB) + angiotensin receptor antagonist (ARB) or angiotensin-converting enzyme inhibitor (ACEI) or thiazide diuretics, etc. Therefore, amlodipine besylate is not recommended for patients with a history of allergy. Therefore, amlodipine benzenesulfonate can be used in combination with ARBs such as valsartan and timosartan, ACEIs such as benazepril and captopril, and thiazide diuretics such as hydrochlorothiazide, etc. However, it should be co-administered under the guidance and recommendation of a cardiologist to avoid inappropriate use that may affect the therapeutic efficacy and cause adverse reactions. Amlodipine benzenesulfonate may cause adverse reactions such as arrhythmia, hypotension, sensory abnormalities, flushing, back pain, etc. If discomfort occurs during use, medical attention should be sought promptly.