Always waking up at 4:00 to 5:00 may be caused by autonomic disorder, diabetes, hypoglycemia and other factors, and need to go to the hospital to clarify the cause. 1. Autonomic nerve disorder: If the patient is under too much stress and can’t relax mentally, resulting in excessive nerve tension, there may be cases of waking up in the middle of the night when sleeping. 2. Diabetes: If the patient’s own blood sugar control is unstable, paroxysmal hypoglycemia may occur in the middle of the night, with symptoms such as panic and sweating, and sudden awakening. Always wake up at 4:00 to 5:00, accompanied by uncomfortable symptoms, the patient needs to go to the hospital in time to improve the relevant examination, clear the cause of the disease, and then follow the doctor’s instructions for relevant treatment.