Significant increase in immunoglobulin IgG and decrease in other immunoglobulins suggests that the patient may have autoimmune diseases, tumors, liver diseases, infectious diseases and other diseases, which need to be further diagnosed. Immunoglobulin IgG is the main component of human serum involved in immunity, with anti-infection, immune regulation and other functions, immunoglobulin IgG increased significantly, other immunoglobulin decreased suggests that the patient may have autoimmune diseases, tumors, liver diseases, infectious diseases, etc., and need to further improve the CRP, sedimentation, autoantibodies, tumor markers and other auxiliary tests. It should be noted that immunoglobulin IgG increased significantly, other immunoglobulin decrease can only provide corresponding clues for clinical diagnosis, but can not confirm a certain disease, the final diagnosis should be combined with the patient’s physical signs, medical history, symptoms and other factors comprehensive analysis. Laboratory test reports need to be interpreted by a professional physician, if the above abnormalities occur, it is recommended that patients go to the relevant departments of regular hospitals for detailed consultation.