Chronic periapical inflammation granulation is more difficult to cure compared to other types of periapical inflammation due to the longer course of the disease, and it requires active cooperation with root canal treatment to be completely cured. 1. The problem of chronic periapical granuloma is mainly due to the inflammatory substances in the root canal have not been thoroughly cleaned up for a long time, the inflammation enters the periapical tissues through the apical foramen and presents proliferative fibrous granulation tissues, or transformed from acute or chronic periapical abscess, which makes it more difficult to cure the periapical inflammation. 2. When chronic apical granuloma occurs, it is necessary to go to the stomatology department of the hospital to take apical radiographs to confirm the scope of apical inflammation, and then carry out systematic endodontic treatment to thoroughly clean the infected material in the root canal and then carry out tight filling, so as to prevent bacteria from re-entering the root canal and causing secondary infection, which will reduce the cure rate. 3. For some chronic periapical infections with too large an extent of inflammation, which cannot be cured by conventional root canal treatment, it is necessary to cooperate with apical surgery and other means to scrape away the granulation tissue, and at the same time, it is also necessary to carry out endodontic treatment as well as inverted filling of the root canal. In addition, if the chronic periapical periodontitis fails to improve for a long period of time even after root canal treatment, extraction of the tooth should be considered to prevent granulation tissue from proliferating and causing bone destruction in the alveolar bone.