Early manifestations of premature renal failure: 1. The patient may not have any systemic symptoms. 2. The patient may have foamy urine, facial and eyelid edema or mild edema of both lower limbs. 3. The patient may have abnormal urinalysis and an obvious increase in blood creatinine on renal function tests during physical examination.3. The patient may have gastrointestinal reactions, most commonly anorexia, with a marked decrease in appetite.4. The patient may have nausea, or even vomiting in the aggravated stage.5. Systemic reactions, and the patient may suffer from generalized fatigue. Patients with such symptoms are recommended to go to nephrology specialists, laboratory tests of renal function to find out whether the blood creatinine increased, once found that the blood creatinine increased, indicating that there has been nearly three-quarters of the renal function decreased significantly, it is recommended that the patient to dietary control, reduce the intake of protein diets, reduce the water dietary intake, control the volume, alleviate edema, and other comorbidities, if they appear, should be treated under the guidance of a specialist. Other comorbidities, if any, should be treated under the guidance of a specialist.