In the clinic, we often have patients who ask us, “Doctor, can I do without insulin?” “Doctor, is it time for me to use insulin?” “Doctor, when can I use insulin?” . Almost every day, this scenario plays out. In fact, the use of insulin is determined by the function of your pancreas. When your pancreas function is very poor and not using insulin may endanger your life, you have to live on it. Indications for insulin: 1. Type 1 diabetes requires lifelong insulin replacement therapy regardless of the severity of the disease and the presence of acute and chronic complications, and cannot be stopped suddenly. Type 2 diabetes mellitus also needs insulin treatment in the following cases: After reasonable diet and exercise and oral hypoglycemic therapy, the blood glucose control still does not reach the standard. Those whose oral hypoglycemic drugs have failed. Patients with wasting that is difficult to be typed. Patients with concomitant acute metabolic disorders, including ketoacidosis, non-ketotic hyperosmolar coma, and lactic acidosis. Patients with concomitant infections, wasting diseases, severe hepatic and renal pathologies, retinopathy, acute myocardial infarction, cerebrovascular accidents, and other stressful states; or severe chronic complications. Pregnancy, childbirth, severe trauma and the perioperative period of medium and major surgery. If the first diagnosis of type 2 diabetes is fasting blood sugar of 10.0mmol/L, 2 hours after meal of 13.0mmol/L and glycated hemoglobin of 9.0%, insulin intensive treatment can be given as early as possible to restore part of the islet function. 3.Other types of diabetes, such as pancreatic diabetes, steroidal diabetes, pituitary diabetes, gestational diabetes, etc.