Gliclazide extended-release tablets and metformin can generally be taken at the same time, but need to be used under the guidance of a doctor. Gliclazide and metformin are both hypoglycemic drugs, but they do not have the same hypoglycemic principle, there is usually no drug conflict, and the combination of the two will usually play a better role. Metformin is the first-line drug for the treatment of type 2 diabetes, which can reduce the output of glucose in the liver to avoid excessive release of glucose into the blood. Adverse reactions such as nausea, vomiting, diarrhea, abdominal pain, bloating, dyspepsia, and fatigue may occur in some patients using this drug, and it is contraindicated in patients who are allergic to the drug and those with liver or kidney insufficiency. Gliclazide belongs to the sulfonylurea class of drugs, mainly by promoting the body’s secretion of insulin, and then play a role in lowering blood sugar. Some patients using the drug occasionally have mild nausea, epigastric pain, constipation, diarrhea, urticaria, thrombocytopenia, granulocytopenia, anemia and other adverse reactions. Severe hepatic and renal insufficiency is prohibited. Patients who need to use Metformin and Gliclazide at the same time should be under the guidance of a doctor, so as to avoid the phenomenon of hypoglycemia caused by too rapid a decrease in blood sugar.