Painful obesity disease mainly manifests as painful nodules or fat masses on top of obesity. Painful obesity is a rare autonomic nervous system disorder of unknown etiology, manifesting as an abnormal accumulation of subcutaneous fat in certain areas of the trunk and accompanied by spontaneous pain in that area. The disease was first described by Dercum (1892) and is therefore also known as Dercum’s disease. What are the prevention methods of obesity and painful nodules or fat masses? 1.Improve the awareness of health fully understand the harm of obesity to human body, understand people in infancy, adolescence, before and after pregnancy, menopause, old age each age stage easy to fat knowledge and prevention methods. Parents should assist children to control weight, careful to prevent future obesity. 2, a balanced and reasonable diet to adopt a reasonable diet, so that the daily three meals regularly rationed, scientific arrangements for the daily diet, such as diet is not greasy, not sweet and not too much, it is appropriate to increase the consumption of vegetables and coarse grains, less fatty sweet and thick taste, more vegetarian, less snacks. 3, strengthen sports and exercise often participate in jogging, climbing, playing ball and other outdoor activities, can enhance physical fitness, make the body fit, but also to prevent the occurrence of obesity. Weight loss people should pay attention to the speed of weight loss: mild obesity can lose 0.5 ~ 1.0kg per month, moderate obesity can lose 0.5 ~ 1.0kg per week. 4, regular life Maintain good living habits, according to the age of different reasonable arrangements for their sleep time, both to meet the physiological needs, but also can not sleep too much. 5, keep a good mood good mood can make the body systems of physiological functions to maintain normal operation, to prevent obesity can play a role. At present, there is no special treatment for this disease, mainly symptomatic treatment, such as the treatment of pain, debility and mental symptoms. For the abnormal accumulation of fat can be applied to aspiration methods to reduce pain, but also for the pain of local lidocaine (lidocaine) injection or intravenous drip, or simply oral painkillers or mexiletine (slow heart rhythm). In the literature, long-term pain relief has been reported in cases of combined chronic hepatitis C treated with interferon (interferon alpha-2b).