Combined liver division and portal vein branch ligation stepwise hepatectomy (ALPPS) is mainly for large hepatocellular carcinoma that invades too much normal liver tissue or requires excision of too much normal liver tissue in special location, and conventional resection is not feasible due to too little remaining normal liver tissue. The second step is to remove the diseased side of the liver after the compensatory growth of the liver. The following example illustrates this. A middle-aged male with a history of hepatitis B. His CT showed a right giant hepatocellular carcinoma exceeding the right half of the liver and a mildly enlarged spleen. The right hepatic giant hepatocellular carcinoma with mild cirrhosis, due to the small size of the remaining liver (patient 66K, 408ml of liver will be left), should not be removed at one time, the whole department decided to do ALPPS. 1 week after the first step of ALPPS, the CT was rechecked and showed that the left liver had grown significantly, reaching 655ml, and then the second step of surgery was completed. The postoperative recovery was smooth. There was no tumor recurrence on the postoperative follow-up 3 months later.